According to Makoto Taketo, MD, DMedSc, a professor of pharmacology at Japan's Kyoto University Graduate School of Medicine, these "aspirin-like NSAIDs" act pharmacologically as anti-inflammatory agents and analgesics and, in so doing, they reduce fever. Blocking it, he adds, isn't harmful, because it doesn't disrupt normal function. Gary J Kelloff, MD, a researcher at the National Cancer Institute, US, who lists the requirements for a molecular tar-get, such as the COX-2 enzyme, says it must be highly expressed in pre-cancer, or cancer cells, and not in others. This is, indeed, the fun-damental reason why researchers have designed coxibs with a definitive purpose: to crush inflammation.ĬOX-2 inhibitors have emerged as lead players for preventing cancer, an inflammatory disorder also, its recurrence. In another study, a randomised comparison of coxib drugs, such as celebrex and indomethacin, suggested that they caused clinically inconsequential and transitory retention of sodium, but no real slump in kidney filtration rate. A meta-analysis (research synthesis) on the effect of NSAIDs on post-operative kidney function reports a clinically unimportant and short-lived reduction in renal function with NSAIDs.
Research suggests that this could be accountable for certain cases of peripheral oedema (swelling) seen in clinical trials. It may also be emphasised that conventional NSAIDs and COX-2 inhibitors subdue renal, or kidney, activity. In an editorial published in "The Journal of the American Medical Association", it was estimated that for low-risk patients for whom the hazard of developing a NSAID-related ulcer complication is 0.4 per cent, the cost of preventing a single complication was US$350,000. M圜DS.In addition to this, as evidence for damage continues to ascend with traditional, or conventional, NSAIDs in causing deaths,reports suggest that on an average 1 in 1,200 patients taking them for at least four weeks could die from gastro-duodenal complications. "1|How are you?" - start text to speech conversion with current selected narratorĮxample connection from C/C++ application:Ĭhar* sendCommand="0|C:\\music\\test.mp3" "0|C:\music\good.mp3" - start playing good.mp3 file "3|13|2.55"Ĭommand X=4 ( set sound fx ), Y - (1-4) - selected effect (0:disable)Ĭommand X=5 ( set sound volume ), Y - (0-100)Ĭommand X=6 ( enable VST effect ), Y - (string) - "disable", "configure", "VST name"Ĭommand X=7 ( music control ), Y - 0:pause 1:resumeĬommand X=8 ( activate profile ), Y - profile name X - numeric comand, Y-string/numeric valueĬommand X=0 ( start audio file ), Y - is file locationĬommand X=1 ( start text to speech ), Y - text to be convertedĬommand X=2 ( enable/disable Clownfish ), Y - 0/1Ĭommand X=3 ( set voice changer ), Y - (0-14) - selected voice (0:none)Ĭommand Custom pitch 3|13|Z - Z float pitch level (-15.0 to +15.0) ex. Sent command should be utf8 encoded string in this format "X|Y".
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You can control Clownfish by sending windows messages from your application( see Data Copy )
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